A meta-analysis of studies measuring blood concentrations of zinc in some 1,600 depressed subjects and 800 control subjects has found that zinc concentrations were significantly lower in the patients with depression. And in the studies that measured depressive symptoms, greater depression severity was associated with a greater relative zinc deficiency. The senior researcher was Krista Lanctot, Ph.D., of the University of Toronto, and results are published in Biological Psychiatry.

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