774 - Neuron Connection - Pattern

One of the greatest ways to fight stigma is to teach our loved ones about bipolar disorder’s biological basis.

Some people do not know that bipolar disorder is truly a medical illness that has been documented in imaging studies.

I continue to research medical evidence behind the illness to help explain bipolar to the people in my life, because overall, it makes my condition more concrete and understandable.
Did you know that these parts of our neuroanatomy and biochemistry have been linked to bipolar disorder?

Our Different Neuroanatomy…
Two cortical circuits are involved in mood dysregulation, which can lead to the development of a mood disorder.

What we don’t know yet is if they are affected during the course of the illness, or whether these areas of the brain cause the disease in the first place.

Another theory: abnormalities in these circuits cause a biological vulnerability, which combines with environmental factors to cause bipolar disorder.

Brain areas involved with bipolar disorder include the forebrain, hippocampus, limbic system, and cerebral cortex.

The cerebral cortex, which helps control thought processes, is affected during bipolar depression.

Other findings in bipolar patients:
  • Decrease in glial cells.
  • Decrease in neurons in the hippocampus.
  • Increase in levels of neuropeptides in the hypothalamus.
  • Decrease in cerebellum size.
  • Reduced activity in prefrontal cortex in depression stage.
…And Different Biochemistry
Neurotransmitters are affected in patients with bipolar disorder.
Cell functioning is negatively affected under the control of these neurotransmitters.
Other findings in bipolar patients:
  • Lower than normal levels of choline have been found.
  • Monoamines such as serotonin and depression are depleted.
  • Noradrenaline is reduced.
  • There is evidence of brain signaling system dysfunction.

Read more at Psych Central